De Matteis M A, Morrow J S
Department of Cell Biology and Oncology, Consorzio Mario Negri Sud, Santa Maria Imbaro, Chieti, Italy.
Curr Opin Cell Biol. 1998 Aug;10(4):542-9. doi: 10.1016/s0955-0674(98)80071-9.
Recent discoveries reveal a Golgi-centric spectrin-ankyrin skeleton required for Golgi integrity and anterograde protein trafficking. Identification of specific functional domains in spectrin that mediate its association with motor proteins and the Golgi complex has allowed novel insights into the structure and function of the secretory pathway, and into how this process is controlled by ADP-ribosylation factor and phosphoinositides. Alternative models of Golgi spectrin function that have been recently proposed are reviewed.
最近的发现揭示了一种以高尔基体为中心的血影蛋白-锚蛋白骨架，它是高尔基体完整性和顺向蛋白质运输所必需的。对血影蛋白中介导其与运动蛋白和高尔基体复合体结合的特定功能域的鉴定，为分泌途径的结构和功能以及该过程如何由ADP-核糖基化因子和磷酸肌醇控制提供了新的见解。本文综述了最近提出的高尔基体血影蛋白功能的替代模型。
