Glazkov M V
Vavilov Institute of General Genetics, Russian Academy of Sciences, Moscow, Russia.
Genetika. 1998 May;34(5):593-604.
Extensive evidence indicates that eukaryotic chromosomes are organized as sets of structural-functional units (domains) that form the basis of independent gene activity. At present, several types of chromosome regions have been suggested for the role of putative domain boundaries between structural-functional units in eukaryotic chromosomes. In this review, the experimental data on several chromosome elements as possible boundaries in eukaryotic chromosomes are presented. They are: scs/scs'-elements of the Drosophila heat-shock locus, DCR, LCR and the insulator of the human and chicken beta-globin locus, as well as MARs (SARs) of plant and animal chromosomes.
大量证据表明，真核生物染色体是作为构成独立基因活性基础的结构功能单元（结构域）集合而组织起来的。目前，已提出几种类型的染色体区域，作为真核生物染色体中结构功能单元之间假定的结构域边界。在这篇综述中，呈现了关于几种染色体元件作为真核生物染色体中可能边界的实验数据。它们是：果蝇热休克基因座的scs/scs'元件、人类和鸡β-珠蛋白基因座的DCR、LCR和绝缘子，以及动植物染色体的MAR（SAR）。
