Osipova T B, Sinel'shchikova T A, Perminova I N, Zasukhina G D
Institute of the Problems of Industrial Ecology of the North, Kola Research Center, Russian Academy of Sciences, Apatity, Russia.
Genetika. 1998 Jun;34(6):852-6.
The genetic activity of nickel sulfate was estimated from the viability, decreased DNA replication, and increased DNA repair synthesis in cultured human fibroblasts and peripheral blood lymphocytes. All but the viability tests showed the mutagenic effect of nickel sulfate. Pretreatment with ascorbic acid modified DNA repair synthesis and increased the viability of lymphocytes treated with nickel sulfate.
通过培养的人成纤维细胞和外周血淋巴细胞的活力、DNA复制减少以及DNA修复合成增加来评估硫酸镍的遗传活性。除活力测试外，所有测试均显示硫酸镍具有诱变作用。用抗坏血酸预处理可改变DNA修复合成，并提高经硫酸镍处理的淋巴细胞的活力。
