在用雌二醇 - 3N - 双（2 - 氯乙基）氨基甲酸盐 - 17β - 磷酸盐（癌腺治）及其雌激素和细胞抑制剂部分进行体内治疗后，将³H - 胸腺嘧啶核苷和¹⁴C - 氨基酸掺入腹侧前列腺。
Incorporation of 3H-thymidine and 14C-amino acids into the ventral prostate after in vivo treatment with estradiol-3N-BIS(2-chloroethyl)carbamate-17 beta-phosphate (Estracyt) and its estrogen and cytostatic parts.
作者信息
Hoisaeter P A
出版信息
Invest Urol. 1976 Sep;14(2):85-92.
The in vivo effect of Estracyt (a nitrogen mustard linked to estradiol-17 beta-phosphate) on testosterone-stimulated incorporation of 3H-thymidine and 14C-amino acids into the ventral prostate of castrated rats has been investigated. A dose of 100 mg of Estracyt per kg of body weight injected intravenously daily for 3 days significantly reduced isotope incorporation. Equivalent amounts of the two main components of Estracyt, the nitrogen mustard and estradiol-17 beta-phosphate, were not able to mimic this Estracyt effect. Possible implications of this difference and the intracellular mechanism of action of Estracyt are discussed.
已对雌氮芥（一种与磷酸雌二醇-17β相连的氮芥）对睾酮刺激的3H-胸腺嘧啶核苷和14C-氨基酸掺入去势大鼠腹侧前列腺的体内效应进行了研究。每天静脉注射剂量为每千克体重100毫克的雌氮芥，连续注射3天，可显著降低同位素掺入。雌氮芥的两种主要成分，即氮芥和磷酸雌二醇-17β，等量时无法模拟雌氮芥的这种效应。讨论了这种差异的可能影响以及雌氮芥的细胞内作用机制。
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