从可食用海藻中分离出的n-3多不饱和脂肪酸对MC/9小鼠肥大细胞类二十烷酸生成的抑制作用。
Inhibition of icosanoid production in MC/9 mouse mast cells by n-3 polyunsaturated fatty acids isolated from edible marine algae.
作者信息
Ishihara K, Murata M, Kaneniwa M, Saito H, Shinohara K, Maeda-Yamamoto M
机构信息
Marine Biochemistry Division, National Research Institute of Fisheries Science, Yokohama, Japan.
出版信息
Biosci Biotechnol Biochem. 1998 Jul;62(7):1412-5. doi: 10.1271/bbb.62.1412.
The effects of two polyunsaturated fatty acids, 18:4n-3 and 16:4n-3 purified from the marine algae, Undaria pinnatifida and Ulva pertusa, on icosanoid production in MC/9 mouse mast cells were assessed. Both fatty acids suppressed the production of leukotriene B4 (LTB4), leukotriene C4 (LTC4), and 5-hydroxyeicosatetraenoic acid (5-HETE). The order of the suppressive activity for the two marine algae-derived fatty acids and three other common polyunsaturated fatty acids was as follows; 22:6n-3 = 18:4n-3 = 18:3n-3 > 20:5n-3 = 16:4n-3 for LTB4; 22:6n-3 = 18:4n-3 = 18:3n-3 > 16:4n-3 > 20:5n-3 (no suppression) for LTC4; 22:6n-3 = 18:4n-3 > 18:3n-3 > 20:5n-3 = 16:4n-3 for 5-HETE.
评估了从海带和孔石莼这两种海藻中纯化得到的两种多不饱和脂肪酸18:4n-3和16:4n-3对MC/9小鼠肥大细胞中类花生酸生成的影响。两种脂肪酸均抑制白三烯B4（LTB4）、白三烯C4（LTC4）和5-羟基二十碳四烯酸（5-HETE）的生成。这两种海藻衍生脂肪酸与其他三种常见多不饱和脂肪酸的抑制活性顺序如下：对于LTB4，22:6n-3 = 18:4n-3 = 18:3n-3 > 20:5n-3 = 16:4n-3；对于LTC4，22:6n-3 = 18:4n-3 = 18:3n-3 > 16:4n-3 > 20:5n-3（无抑制作用）；对于5-HETE，22:6n-3 = 18:4n-3 > 18:3n-3 > 20:5n-3 = 16:4n-3。
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