Uda R, Ohtsuka M, Doi Y, Inamori K, Kunimasa K, Ohnaka M, Minami T, Akatsuka M, Mori H
Department of Anesthesiology, Osaka Medical College, Takatsuki.
Masui. 1998 Jul;47(7):843-7.
We evaluated the efficacy of the 60% lidocaine tape in alleviating pain associated with intravenous propofol administration in 71 gynecological patients. Thirty-eight women had the tape applied for 2.5 h before venipuncture, with the remaining patients acting as the control. A 20 gauge cannula was inserted into the cephalic vein. Propofol at room temperature was injected at a rate of 1200 ml.hr-1. The statistical significance of differences was established with the Mann-Whitney's U test and the chi 2 test. The median level of pain intensity resulting from venipuncture among the patients treated with the tape was smaller than that in the control group (16.5, vs 34, P = 0.006). Thereafter, cannulation was successfully achieved with reduced or no pain (VAS at cannulation < or = 25, n = 39), and only 16% of the treatment group complained of pain on injection as compared with 53.8% of the control group (P = 0.02). Moreover, the pain intensity was decreased with lidocaine tape (P = 0.006). The cost of the lidocaine tape is covered by medical insurance for reducing pain on venipuncture. Thus, as the tape also alleviates the pain on injection of propofol through its anesthetic action, it can be a safe, easy and cost-effective method as "it kills two pains with one tape".
我们评估了60%利多卡因贴剂在减轻71例妇科患者静脉注射丙泊酚时相关疼痛方面的疗效。38名女性在静脉穿刺前2.5小时使用该贴剂，其余患者作为对照。将一根20号套管针插入头静脉。室温下的丙泊酚以1200 ml·hr⁻¹的速度注射。采用曼-惠特尼U检验和卡方检验确定差异的统计学意义。使用贴剂治疗的患者中静脉穿刺引起的疼痛强度中位数低于对照组（16.5对34，P = 0.006）。此后，插管成功实现，疼痛减轻或无疼痛（插管时视觉模拟评分≤25，n = 39），治疗组只有16%的患者在注射时抱怨疼痛，而对照组为53.8%（P = 0.02）。此外，利多卡因贴剂可减轻疼痛强度（P = 0.006）。利多卡因贴剂的费用由医疗保险支付，用于减轻静脉穿刺时的疼痛。因此，由于该贴剂还通过其麻醉作用减轻丙泊酚注射时的疼痛，它可以成为一种安全、简便且具有成本效益的方法，即“一贴双止痛”。
