Tamakawa S, Ogawa H
Department of Anesthesia, Rumoi Municipal Hospital.
Masui. 1998 Jul;47(7):882-4.
The treatment of postherpetic neuralgia (PHN) by topical administration of local anesthetics has a number of drawbacks. Lidocaine tape (Penles) is a 15 cm2 dressing tape based on 60% lidocaine used to anesthetize skin when an intravenous catheter is inserted. This study aims to evaluate the analgesic efficacy of lidocaine tape in patients with PHN by comparing the results with those of surgical drape (Tegaderm). In a single-blind, two session study, lidocaine tape or surgical drape was applied to the affected skin of 10 patients. In one session, lidocaine tape was applied to the painful skin area, and in another, surgical drape was applied to the same area. Pain score and side effects were measured over 12 hours. Pain score was reduced at measurements taken starting from 1 hour after lidocaine tape application (P < 0.05). Lidocaine tape induced minor side-effects, erythema in a patient and increase in pain in another patient. In conclusion, lidocaine tape is effective for relief of PHN.
局部应用局部麻醉药治疗带状疱疹后神经痛（PHN）存在诸多弊端。利多卡因贴剂（Penles）是一种面积为15平方厘米的敷料贴，含60%利多卡因，用于在插入静脉导管时麻醉皮肤。本研究旨在通过将结果与手术巾（泰德 Derm）的结果进行比较，评估利多卡因贴剂对PHN患者的镇痛效果。在一项单盲、分两阶段的研究中，将利多卡因贴剂或手术巾应用于10例患者的受累皮肤。在一个阶段，将利多卡因贴剂应用于疼痛皮肤区域，在另一个阶段，将手术巾应用于同一区域。在12小时内测量疼痛评分和副作用。从应用利多卡因贴剂1小时后开始测量时，疼痛评分降低（P<0.05）。利多卡因贴剂引起轻微副作用，1例患者出现红斑，另1例患者疼痛加重。总之，利多卡因贴剂对缓解PHN有效。
