Borota R, Borota J, Belić A, Gebauer E, Stefanović N, Dozić L
Zavod za patolosku fiziologiju, Medicinski fakultet, Novi Sad.
Med Pregl. 1998 May-Jun;51(5-6):231-5.
Estimation of the effect of sera obtained from patients suffering from several forms of megakaryocytic (immune) thrombocytopenia (19), and those with acute non-lymphoblastic leukemia (13), on the platelet count in the peripheral blood of mice was carried out. Several groups of mice were injected intravenously with 0.2 ml of patients' sera, and the platelet count was followed up for 10 days. A marked and highly significant decrease of platelet count in recipient mice was established even 6 hours after the application of both groups of patients' sera. In the control group of mice receiving pooled serum of healthy persons this decrease was not registered. It can be presumed with great probability that the mechanism of development of thrombocytopenia in both groups of patients is very similar: there is an extremely increased destruction of platelets in the peripheral blood in cases with immune thrombocytopenia by antibodies, and in cases with acute leukemias by antibodies and/or other cytotoxic substances. In further investigations the influence of thrombopoietin on this phenomenon will be tested.
对患有多种形式巨核细胞（免疫性）血小板减少症（19例）和急性非淋巴细胞白血病（13例）患者的血清对小鼠外周血血小板计数的影响进行了评估。几组小鼠静脉注射0.2 ml患者血清，并对血小板计数进行了10天的跟踪。在应用两组患者血清后6小时，受体小鼠的血小板计数就出现了明显且高度显著的下降。在接受健康人混合血清的小鼠对照组中，未观察到这种下降。极有可能推测，两组患者血小板减少症的发生机制非常相似：在免疫性血小板减少症病例中，外周血中的血小板因抗体而被极度破坏，在急性白血病病例中，则因抗体和/或其他细胞毒性物质而被破坏。在进一步的研究中，将测试血小板生成素对这一现象的影响。
