[A new Russian combined antihypertensive preparation proxopheline in the treatment of glaucoma].

Tolerance and efficacy of a new combined antiglaucoma drug proxopheline (1% proxodolol and 0.25% clopheline) is assessed. Studies in 43 patients (63 eyes) with open-angle glaucoma showed that a single instillation of the drug decreases intraocular pressure in 1 h and in 93% of patients the hypotensive effect persists for up to 24 h. Prolonged (4 weeks) use of proxopheline resulted in normalization of intraocular pressure in 90% of treated eyes. The main side effect was dryness in the mouth (30%). The hypotensive effect of proxopheline is superior to that of proxodolol, but it involves a higher incidence of side effects, caused by clopheline--another component of proxopheline.