[DnaA蛋白的功能，大肠杆菌染色体DNA复制的起始因子]
[Function of DnaA protein, the initiator for chromosomal DNA replication in E. coli].
作者信息
Mizushima T
机构信息
Faculty of Pharmaceutical Sciences, Okayama University, Japan.
出版信息
Yakugaku Zasshi. 1998 Jul;118(7):257-71. doi: 10.1248/yakushi1947.118.7_257.
DnaA protein is an initiator for chromosomal DNA replication in E. coli. We have examined the function of the protein to answer the following four questions; 1. How DnaA protein is inactivated after DNA replication for the suppression of re-initiation? 2. How DnaA protein is activated for the initiation of DNA replication? 3. Does DnaA protein have functions other than that for DNA replication? 4. Is DnaA protein is a good target for new antibiotics? In this review, I summarize our recent studies for these questions.
DnaA蛋白是大肠杆菌染色体DNA复制的起始因子。我们研究了该蛋白的功能，以回答以下四个问题：1. DNA复制后DnaA蛋白如何失活以抑制再次起始？2. DnaA蛋白如何被激活以起始DNA复制？3. DnaA蛋白是否具有除DNA复制之外的其他功能？4. DnaA蛋白是否是新型抗生素的良好靶点？在这篇综述中，我总结了我们最近针对这些问题的研究。
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