Lagneaux L, Delforge A, Bernier M, Stryckmans P, Bron D
Service de Médecine Interne et Laboratoire d'Investigation Clinique Henri Tagnon, Institut J. Bordet, Brussels, Belgium.
Leuk Lymphoma. 1998 Sep;31(1-2):99-106. doi: 10.3109/10428199809057589.
B-cell chronic lymphocytic leukemia (B-CLL) is the most common leukemia in Western countries and results from the accumulation of B-lymphocytes which are functionally abnormal and predominantly non-cycling in vivo. Consequently, it is important to understand why B-CLL cells accumulate in GO phase. Since TGF-beta is an important negative regulator of the immune system, a loss of responsiveness to this factor might provide a selective advantage to B-CLL cells. Here we review data on the role of TGF-beta in B-CLL. We show that the B-CLL cell response to TGF-beta signals is abnormal in vitro (inhibition of proliferation and induction of apoptosis). This lack of response of B-CLL cells to TGF-beta inhibition appears to be accompanied by a decrease or a loss of TGF-beta receptor expression.
B细胞慢性淋巴细胞白血病（B-CLL）是西方国家最常见的白血病，由功能异常且在体内主要处于非循环状态的B淋巴细胞积累所致。因此，了解B-CLL细胞为何在G0期积累很重要。由于转化生长因子β（TGF-β）是免疫系统的重要负调节因子，对该因子反应性的丧失可能为B-CLL细胞提供选择性优势。在此，我们综述了关于TGF-β在B-CLL中作用的数据。我们发现，B-CLL细胞在体外对TGF-β信号的反应是异常的（增殖受抑制和凋亡被诱导）。B-CLL细胞对TGF-β抑制缺乏反应，这似乎伴随着TGF-β受体表达的减少或丧失。
