Bondurand N, Kobetz A, Pingault V, Lemort N, Encha-Razavi F, Couly G, Goerich D E, Wegner M, Abitbol M, Goossens M
Laboratoire de Génétique Moléculaire et Physiopathologie, Institut National de la Santé et de la Recherche Médicale, U.468, Hôpital Henri Mondor, Créteil, France.
FEBS Lett. 1998 Aug 7;432(3):168-72. doi: 10.1016/s0014-5793(98)00843-6.
SOX10, a new member of the SOX gene family, is a transcription factor defective in the Dom (Dominant megacolon) mouse and in the human Shah-Waardenburg syndrome. To help unravel its physiological role during human development, we studied SOX10 gene expression in embryonic, fetal, and adult human tissues by Northern blot and in situ hybridization. As in mice, the human SOX10 gene was essentially expressed in the neural crest derivatives that contribute to the formation of the peripheral nervous system, and in the adult central nervous system. Nevertheless, it was more widely expressed in humans than in rodents. The spatial and temporal pattern of SOX10 expression supports an important function in neural crest development.
SOX10是SOX基因家族的一个新成员，是一种在Dom（显性巨结肠）小鼠和人类沙-瓦登伯格综合征中存在缺陷的转录因子。为了有助于阐明其在人类发育过程中的生理作用，我们通过Northern印迹法和原位杂交技术研究了SOX10基因在人类胚胎、胎儿及成人组织中的表达情况。与小鼠一样，人类SOX10基因主要在有助于外周神经系统形成的神经嵴衍生物以及成人中枢神经系统中表达。然而，它在人类中的表达比在啮齿动物中更为广泛。SOX10表达的时空模式支持其在神经嵴发育中具有重要功能。
