Takebayashi M, Kagaya A, Uchitomi Y, Kugaya A, Muraoka M, Yokota N, Horiguchi J, Yamawaki S
Department of Psychiatry and Neurosciences, Hiroshima University School of Medicine, Japan.
J Neural Transm (Vienna). 1998;105(4-5):537-42. doi: 10.1007/s007020050077.
We investigated plasma dehydroepiandrosterone sulfate (DHEAS) and cortisol levels in 12 patients with unipolar depression and 11 matched normal controls. The depressed patients showed significantly higher values of plasma DHEAS and cortisol than the controls. After 4 weeks of treatment with antidepressants (mainly clomiplamine), the high plasma DHEAS levels recovered. This finding showed the possible relationship between plasma DHEAS levels and depression, as well as cortisol levels.
我们研究了12例单相抑郁症患者和11例匹配的正常对照者的血浆硫酸脱氢表雄酮（DHEAS）和皮质醇水平。抑郁症患者的血浆DHEAS和皮质醇水平显著高于对照组。在用抗抑郁药（主要是氯米帕明）治疗4周后，血浆DHEAS的高水平恢复正常。这一发现表明血浆DHEAS水平与抑郁症以及皮质醇水平之间可能存在关联。
