Alexander J M, Nyby M D, Jasberg K A
J Appl Physiol. 1976 Jul;41(1):84-8. doi: 10.1152/jappl.1976.41.1.84.
The effects of infused angiotensin on hypoxic pulmonary vasoconstriction in blood-perfused isolated dog lungs were studied. By using a double-perfusion system we were able to perfuse the right and left lungs separately in the same animal; one lung was used as control and the other lung was experimentally modified. The vasoconstrictive response to hypoxia decreased with time in the isolated lung preparations. The infusion of either angiotensin I or angiotensin II (1.2-5.8 mug/min) caused a threefold increase in the vasoconstrictive response to hypoxia over control levels. A second hypoxic period during the infusion usually yielded a diminished response, suggesting further degeneration of the response irreversible with angiotensin. It was concluded that angiotensin I or angiotensin II temporarily enhances hypoxic pulmonary vasoconstriction in isolated dog lungs.
研究了输注血管紧张素对血液灌注的离体犬肺缺氧性肺血管收缩的影响。通过使用双灌注系统，我们能够在同一动物中分别灌注右肺和左肺；一个肺作为对照，另一个肺进行实验性处理。在离体肺标本中，对缺氧的血管收缩反应随时间降低。输注血管紧张素I或血管紧张素II（1.2 - 5.8微克/分钟）使对缺氧的血管收缩反应比对照水平增加了三倍。输注期间的第二个缺氧期通常产生减弱的反应，表明血管紧张素导致的反应进一步退化且不可逆。得出的结论是，血管紧张素I或血管紧张素II可暂时增强离体犬肺的缺氧性肺血管收缩。
