Hanley N A, Bourke J P, Gascoigne A D
Intensive Therapy Unit, Royal Victoria Infirmary, Newcastle-upon-Tyne, UK.
Intensive Care Med. 1998 Jul;24(7):740-2. doi: 10.1007/s001340050655.
Flecainide acetate is a potent class Ic anti-arrhythmic drug with major sodium channel blocking actions. On the surface electrocardiogram this results in QTc interval prolongation. Overdose with class Ic drugs (< 0.1% of total intoxications) is uncommon, but management is difficult and the mortality high [1]. Serious flecainide overdose is characterised by ventricular tachyarrhythmias, severe bradycardia and variable degrees of atrioventricular block. This report describes a case of life-threatening flecainide overdose in a previously fit individual, resulting in a combination of cardiac disturbances. The treatment options and management are discussed.
醋酸氟卡尼是一种强效的Ic类抗心律失常药物，具有主要的钠通道阻滞作用。在体表心电图上，这会导致QTc间期延长。Ic类药物过量（占全部中毒的<0.1%）并不常见，但处理困难且死亡率高[1]。严重的氟卡尼过量表现为室性快速性心律失常、严重心动过缓和不同程度的房室传导阻滞。本报告描述了一例既往健康个体发生危及生命的氟卡尼过量病例，导致多种心脏紊乱。文中讨论了治疗选择和处理方法。
