Li C K, Shing M M, Chik K W, Kwan W H, Lai D H, Leung T F, Yuen P M
Department of Paediatrics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong SAR.
Bone Marrow Transplant. 1998 Aug;22(4):397-9. doi: 10.1038/sj.bmt.1701340.
A 7-year-old boy with Ph+ ALL received an allogeneic BMT in second remission. Conditioning included cyclophosphamide 60 mg/kg for 2 days, TBI 2 Gy twice daily for 3 days (12 Gy) and a single testicular boost of 4 Gy. He remained in hematological remission after BMT but developed isolated testicular relapse at 17 months. He underwent orchiectomy of the affected testis, 24 Gy testicular radiotherapy and systemic chemotherapy. He remains in remission 24 months after the testicular relapse. This is the first report of isolated testicular relapse which received a testicular irradiation boost included in the conditioning.
一名7岁的Ph+急性淋巴细胞白血病男孩在第二次缓解期接受了异基因骨髓移植。预处理方案包括环磷酰胺60mg/kg，连用2天，全身照射2Gy，每天2次，共3天（12Gy），并对睾丸进行一次4Gy的增强照射。骨髓移植后他一直处于血液学缓解状态，但在17个月时出现了孤立性睾丸复发。他接受了患侧睾丸切除术、24Gy的睾丸放疗和全身化疗。睾丸复发24个月后他仍处于缓解状态。这是第一例关于在预处理方案中包含睾丸增强照射后出现孤立性睾丸复发的报告。
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