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隐睾内急性髓系白血病复发:病例报告

Recurrence of acute myeloid leukemia in cryptorchid testis: case report.

作者信息

Góes Luccas Santos Patto de, Lopes Roberto Iglesias, Campos Octavio Henrique Arcos, Oliveira Luiz Carlos Neves de, Sant'Anna Alexandre Crippa, Dall'Oglio Marcos Francisco, Srougi Miguel

机构信息

Hospital do Servidor Público Municipal de São Paulo, São Paulo, SP, Brazil.

Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brazil.

出版信息

Einstein (Sao Paulo). 2014 Jan-Mar;12(1):109-11. doi: 10.1590/s1679-45082014rc2689.

DOI:10.1590/s1679-45082014rc2689
PMID:24728256
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4898249/
Abstract

A 23-year-old male with a history of bone marrow transplant for acute myeloid leukemia. He presented a large mass in the right inguinal region 5 years ago. Upon physical examination, right-sided cryptorchidism was observed. The tumor markers alpha-fetoprotein and beta-HCG were within normalcy range and lactate dehydrogenase was raised. Computed tomography of the abdomen and pelvis revealed right testicular mass in contiguity with the inguinal canal to the ipsilateral retroperitoneum, associated with right hydronephrosis. Due to the risk of germ-cell tumor in undescended testicle, the patient underwent radical right orchiectomy. The pathological examination showed recurrence of acute myeloid leukemia in the testis. He was referred to oncology for adjuvant therapy. Our literature review found no similar cases described.

摘要

一名23岁男性,有因急性髓系白血病接受骨髓移植的病史。5年前他右侧腹股沟区出现一个大肿块。体格检查发现右侧隐睾。肿瘤标志物甲胎蛋白和β-人绒毛膜促性腺激素在正常范围内,但乳酸脱氢酶升高。腹部和盆腔计算机断层扫描显示右侧睾丸肿块与腹股沟管至同侧腹膜后相连,伴有右侧肾积水。由于隐睾存在生殖细胞瘤风险,患者接受了右侧睾丸根治性切除术。病理检查显示睾丸内急性髓系白血病复发。他被转诊至肿瘤科进行辅助治疗。我们的文献回顾未发现类似病例报道。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a45/4898249/be3265c7c045/1679-4508-eins-12-01-0109-gf04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a45/4898249/3e03aa562d5d/1679-4508-eins-12-01-0109-gf01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a45/4898249/55a02ef151cf/1679-4508-eins-12-01-0109-gf02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a45/4898249/a80312398e98/1679-4508-eins-12-01-0109-gf03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a45/4898249/be3265c7c045/1679-4508-eins-12-01-0109-gf04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a45/4898249/3e03aa562d5d/1679-4508-eins-12-01-0109-gf01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a45/4898249/55a02ef151cf/1679-4508-eins-12-01-0109-gf02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a45/4898249/a80312398e98/1679-4508-eins-12-01-0109-gf03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a45/4898249/be3265c7c045/1679-4508-eins-12-01-0109-gf04.jpg

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本文引用的文献

1
Acute myeloid leukaemia: optimal management and recent developments.急性髓系白血病:最佳管理和最新进展。
Drugs. 2011 Aug 20;71(12):1537-50. doi: 10.2165/11593060-000000000-00000.
2
An unusual case of acute myeloid leukemia: late isolated testicular relapse followed by isolated central nervous system relapse.一个不寻常的急性髓系白血病病例:晚期孤立性睾丸复发,随后出现孤立性中枢神经系统复发。
Pediatr Blood Cancer. 2010 Dec 1;55(6):1231-3. doi: 10.1002/pbc.22666.
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儿童急性淋巴细胞白血病的睾丸复发:挑战与教训
Indian J Cancer. 2010 Apr-Jun;47(2):134-8. doi: 10.4103/0019-509X.63002.
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Continued complete remission without systemic therapy for isolated testicular relapse after bone marrow transplantation in a boy with acute lymphoblastic leukemia.一名急性淋巴细胞白血病男孩在骨髓移植后出现孤立性睾丸复发,未进行全身治疗但持续完全缓解。
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Diagnosis and treatment of testicular cancer.睾丸癌的诊断与治疗。
Am Fam Physician. 2008 Feb 15;77(4):469-74.
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Cancer statistics, 2008.2008年癌症统计数据。
CA Cancer J Clin. 2008 Mar-Apr;58(2):71-96. doi: 10.3322/CA.2007.0010. Epub 2008 Feb 20.
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Prepubertal orchiopexy for cryptorchidism may be associated with lower risk of testicular cancer.青春期前隐睾症睾丸固定术可能与睾丸癌风险较低有关。
J Urol. 2007 Oct;178(4 Pt 1):1440-6; discussion 1446. doi: 10.1016/j.juro.2007.05.166. Epub 2007 Aug 16.
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Age at surgery for undescended testis and risk of testicular cancer.隐睾手术时的年龄与睾丸癌风险
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Isolated testicular relapse after bone marrow transplant with total body irradiation and testicular boost in acute lymphoblastic leukemia.急性淋巴细胞白血病患者在接受全身照射和睾丸局部照射的骨髓移植后出现孤立性睾丸复发。
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Testicular lymphoblastic leukemia/lymphoma.睾丸淋巴母细胞白血病/淋巴瘤
World J Urol. 1995;13(4):230-2. doi: 10.1007/BF00182968.