McGee E A, Hsu S Y, Kaipia A, Hsueh A J
Department of Gynecology and Obstetrics, Stanford University Medical Center, CA 94305, USA.
Mol Cell Endocrinol. 1998 May 25;140(1-2):15-8. doi: 10.1016/s0303-7207(98)00023-9.
Mammalian germ cells arise in the yolk sac endoderm at the caudal aspect of the embryo and migrate to the mesodermally-derived gonadal ridge early in development. After the oogonia reach the gonadal ridge, the process of meiosis begins which coincides with the first major wave of apoptosis of female germ cells (Coucouvanis et al., 1993). Subsequently, oocytes progress to the dictyate stage of prophase I where they remain arrested until ovulation.
哺乳动物的生殖细胞起源于胚胎尾部的卵黄囊内胚层，并在发育早期迁移至中胚层来源的性腺嵴。卵原细胞到达性腺嵴后，减数分裂过程开始，这与雌性生殖细胞的第一波主要凋亡同时发生（Coucouvanis等人，1993年）。随后，卵母细胞进入减数分裂前期I的双线期阶段，并在该阶段停滞，直至排卵。
