Whittle H C, Ariyoshi K, Rowland-Jones S
MRC Laboratories, The Gambia, West Africa.
Curr Opin Immunol. 1998 Aug;10(4):382-7. doi: 10.1016/s0952-7915(98)80108-8.
HIV-2 is less pathogenic and less transmissible than HIV-1. Recent research in relation to deletions in the HIV nef gene and to immune cross-reactions between infections by HIV-2, HIV-1 and simian immunodeficiency virus suggests that T cell recognition and the control of viral replication may be more efficient in HIV-2 infection than in HIV-1 infection. These insights may be crucial to the design of effective vaccines.
HIV-2的致病性和传染性均低于HIV-1。最近有关HIV nef基因缺失以及HIV-2、HIV-1感染与猿猴免疫缺陷病毒感染之间免疫交叉反应的研究表明，在HIV-2感染中，T细胞识别和病毒复制控制可能比HIV-1感染更有效。这些见解可能对有效疫苗的设计至关重要。
