人白细胞抗原-肽四聚体复合物
HLA-peptide tetrameric complexes.
作者信息
Ogg G S, McMichael A J
机构信息
Institute of Molecular Medicine, Nuffield Department of Medicine, John Radcliffe Hospital, Oxford, UK.
出版信息
Curr Opin Immunol. 1998 Aug;10(4):393-6. doi: 10.1016/s0952-7915(98)80110-6.
PMID:9722914
Abstract
HLA-peptide tetrameric complexes allow the direct ex vivo visualisation of antigen-specific CD8+ T cells and natural killer cells by flow cytometry. Quantitation, phenotypic analysis and isolation of tetramer-binding cells has considerably extended our understanding of cytotoxic T lymphocyte and natural killer cell function.
摘要
HLA-肽四聚体复合物可通过流式细胞术直接在体外可视化抗原特异性CD8+ T细胞和自然杀伤细胞。对四聚体结合细胞进行定量、表型分析和分离，极大地扩展了我们对细胞毒性T淋巴细胞和自然杀伤细胞功能的理解。
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