Dudley C, Kircik L H, Bullen R, Snow S, Landeck A, Buchler D
Department of Surgery, University of Wisconsin, Madison, USA.
Dermatol Surg. 1998 Aug;24(8):889-92. doi: 10.1111/j.1524-4725.1998.tb04268.x.
Cutaneous metastases from vulvar squamous cell carcinomas (SCC) have been reported only twice previously and both patients expired shortly after they occurred. Mohs surgery has been reported in three previous publications as a successful treatment for local invasive vulvar SCC and Bowen's disease.
To describe a third case with cutaneous metastases and 14 other cases of invasive and in situ vulvar SCC treated by fresh tissue Mohs surgery in a pilot study at the University of Wisconsin between 1976 and 1995.
We took photographs of the gross appearance and of the histologic slides of the tumor at the local site and at the metastatic sites on the skin and reviewed patients' charts.
One patient developed pelvic and cutaneous metastases 5 years after radical vulvectomy with bilateral node dissection. She expired shortly after the skin metastases appeared. The courses of the patients followed after Mohs surgery for vulvar SCC were variable.
Cutaneous metastases from vulvar SCC are rare but carry a grim prognosis. Mohs surgery should be considered in select cases to try to prevent excess morbidity and mortality.
外阴鳞状细胞癌(SCC)的皮肤转移此前仅报道过两例,且两名患者均在转移发生后不久死亡。此前有三篇文献报道Mohs手术成功治疗局部浸润性外阴SCC和鲍温病。
描述1976年至1995年在威斯康星大学进行的一项初步研究中,第三例皮肤转移病例以及其他14例浸润性和原位外阴SCC患者接受新鲜组织Mohs手术的情况。
我们拍摄了肿瘤在局部部位以及皮肤转移部位的大体外观和组织学切片照片,并查阅了患者病历。
一名患者在接受根治性外阴切除术及双侧淋巴结清扫术后5年出现盆腔和皮肤转移。皮肤转移出现后不久她便去世。外阴SCC患者接受Mohs手术后的病程各不相同。
外阴SCC的皮肤转移罕见,但预后严峻。在某些特定病例中应考虑采用Mohs手术,以尽量避免过高的发病率和死亡率。