向大鼠脑室内注射促肾上腺皮质激素释放因子（CRF）阻断剂（CRF9 - 41δ螺旋）可减轻吗啡戒断反应。
ICV administration of CRF blocker (CRF9-41 delta helical) reduces morphine withdrawal in rats.
作者信息
Brugger S, Sánchez R, Brugger A J, Martinez J A
机构信息
Department of Physiology and Pharmacology, University School of Medicine, Murcia, Spain.
出版信息
Prog Neuropsychopharmacol Biol Psychiatry. 1998 Jul;22(5):775-85. doi: 10.1016/s0278-5846(98)00039-6.
PMID:9723119
Abstract
- The effects of CRF9-41 delta helical on morphine withdrawal signs in rats were studied. 2. Intracerebroventricular administration of CRF9-41 delta helical 5 at 10 micrograms/kg reduced central and peripheral symptoms of the withdrawal syndrome, such as ptosis, jumping, wet dog shakes and teeth chattering; other signs remained unchanged. The effect were not dose dependent. 3. The hypothermi characteristic of the Withdrawal syndrome was reduced by CRF9-41 delta helical. 4. These results suggest that the hypothalamo pituitary adrenal(HPA) axis play an important role in the morphine withdrawal syndrome in rats.
摘要
- 研究了CRF9 - 41δ螺旋对大鼠吗啡戒断症状的影响。2. 脑室内注射10微克/千克的CRF9 - 41δ螺旋可减轻戒断综合征的中枢和外周症状，如眼睑下垂、跳跃、湿狗样抖动和牙齿打颤；其他症状保持不变。该作用不依赖剂量。3. CRF9 - 41δ螺旋减轻了戒断综合征的体温过低特征。4. 这些结果表明，下丘脑 - 垂体 - 肾上腺（HPA）轴在大鼠吗啡戒断综合征中起重要作用。
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