Galbaud du Fort G, Bland R C, Newman S C, Boothroyd L J
Department of Psychiatry, McGill University, Montreal, Quebec, Canada.
Psychol Med. 1998 Jul;28(4):789-802. doi: 10.1017/s0033291798006795.
Most studies of spouse similarity for psychiatric disorders have focused on clinical samples and are thus limited by selection bias. This study is, to our knowledge, the first comprehensive investigation of spouse similarity for lifetime psychiatric history in a general population sample using standardized diagnostic criteria.
We studied 519 pairs of spouses residing in Edmonton, Canada who completed the Diagnostic Interview Schedule psychiatric interview. In each pair, one spouse belonged to a random subsample of persons who had participated in a large population survey and was re-interviewed. Association between spouses for lifetime DSM-III psychiatric disorders was analysed with bivariate and multivariate logistic regression analyses.
We observed significant spousal association for lifetime presence of affective disorders and for the spectrum of antisocial personality and addiction disorders. Antisocial personality in one spouse was also associated with anxiety disorders in the other spouse, namely post-traumatic stress disorder in wives and phobia in husbands; similarly, drug abuse/dependence in wives was associated with generalized anxiety in husbands and male drug abuse/dependence was associated with female post-traumatic stress disorder. Dysthymia in wives was associated with generalized anxiety and post-traumatic stress disorder in husbands.
The existence of associations between spouses for the presence of psychiatric disorders, either similar or different, has significant implications for both clinicians and researchers. Future research should aim at exploring the aetiological mechanisms of these associations.
大多数关于精神疾病配偶相似性的研究都集中在临床样本上，因此受到选择偏倚的限制。据我们所知，本研究是首次在一般人群样本中使用标准化诊断标准对终生精神病史的配偶相似性进行全面调查。
我们研究了居住在加拿大埃德蒙顿的519对配偶，他们完成了诊断访谈表精神科访谈。在每对配偶中，一方配偶属于参与大型人群调查并接受再次访谈的随机子样本。通过双变量和多变量逻辑回归分析来分析配偶之间终生DSM-III精神疾病的关联性。
我们观察到，在情感障碍的终生患病情况以及反社会人格和成瘾障碍谱系方面，配偶之间存在显著关联。一方配偶的反社会人格也与另一方配偶的焦虑症有关，即妻子的创伤后应激障碍和丈夫的恐惧症；同样，妻子的药物滥用/依赖与丈夫的广泛性焦虑有关，而男性药物滥用/依赖与女性创伤后应激障碍有关。妻子的心境恶劣与丈夫的广泛性焦虑和创伤后应激障碍有关。
配偶之间存在精神疾病患病情况的关联，无论是相似还是不同，这对临床医生和研究人员都具有重要意义。未来的研究应旨在探索这些关联的病因机制。
