使用药理学免疫抑制增强抗淋巴细胞血清处理的小鼠中供体特异性骨髓诱导的对皮肤同种异体移植物的特异性无反应性（耐受性）：西罗莫司的独特作用
Use of pharmacologic immunosuppression to augment the specific unresponsiveness (tolerance) to skin allografts induced by donor-specific bone marrow in antilymphocyte serum-treated mice: the unique effect of sirolimus.
作者信息
Hale D, Gottschalk R, Maki T, Monaco A P
机构信息
Department of Surgery, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02158, USA.
出版信息
Transplant Proc. 1998 Aug;30(5):2432-4. doi: 10.1016/s0041-1345(98)00676-9.
PMID:9723527
Abstract
Tolerance produced with ALS treatment, DSBM, and sirolimus involves multiple mechanisms of a specific and nonspecific nature. In eventual clinical application for tolerance induction, sirolimus (rapamycin) has great potential for augmenting the tolerogenicity of the ALS/BM regimen.
摘要
用抗淋巴细胞血清（ALS）治疗、供体特异性骨髓（DSBM）和西罗莫司产生的耐受性涉及多种特异性和非特异性性质的机制。在最终用于诱导耐受性的临床应用中，西罗莫司（雷帕霉素）在增强ALS/BM方案的致耐受性方面具有巨大潜力。
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