Vaswani S K, Hamilton R G
Johns Hopkins University School of Medicine, Division of Allergy and Clinical Immunology, Baltimore, Maryland, USA.
Ann Allergy Asthma Immunol. 1998 Aug;81(2):105-15; quiz 115-6, 119. doi: 10.1016/S1081-1206(10)62794-9.
Antibodies have been used therapeutically to treat a variety of clinical conditions. The introduction of monoclonal antibodies and more recently, engineered humanized antibodies has greatly refined and expanded the therapeutic potential of this modality of treatment.
To reinforce the reader's knowledge of the therapeutic application of antibody in the treatment for different diseases. More specifically, to enhance reader's understanding of basic methods employed in the production and clinical use of humanized antibodies.
The MEDLINE database was used to review the humanized antibody related literature.
Humanized antibodies provide a novel approach for the treatment of a broad range of diseases. Expanded use will depend on improvement in their efficacy (avidity and specificity), demonstration of their safety, and reduction of their immunogenicity.
抗体已被用于治疗多种临床病症。单克隆抗体的引入，以及最近工程化人源化抗体的出现，极大地完善并扩展了这种治疗方式的治疗潜力。
强化读者对抗体在不同疾病治疗中治疗应用的认识。更具体地说，增强读者对人源化抗体生产和临床使用中所采用基本方法的理解。
使用MEDLINE数据库检索人源化抗体相关文献。
人源化抗体为多种疾病的治疗提供了一种新方法。其更广泛的应用将取决于疗效（亲和力和特异性）的提高、安全性的证明以及免疫原性的降低。
