Effect of direct thrombin inhibition with Bivalirudin (Hirulog) on restenosis after coronary angioplasty.

作者信息

Burchenal J E, Marks D S, Tift Mann J, Schweiger M J, Rothman M T, Ganz P, Adelman B, Bittl J A

机构信息

Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.

出版信息

Am J Cardiol. 1998 Aug 15;82(4):511-5. doi: 10.1016/s0002-9149(98)00371-3.

The direct antithrombin, bivalirudin, did not reduce angiographic restenosis measured either as the dichotomous restenosis rate of 62% for bivalirudin and 58% for heparin (p = 0.70), or as the late loss in lumen diameter of 0.44 +/- 0.47 mm for bivalirudin and 0.39 +/- 0.53 mm for heparin (p = 0.62). Direct thrombin inhibition with bivalirudin neither reduces angiographic restenosis nor alters the impact of several established risk factors for restenosis.