Gross A S
Department of Clinical Pharmacology, Royal North Shore Hospital, St Leonards NSW, Australia.
Br J Clin Pharmacol. 1998 Aug;46(2):95-9. doi: 10.1046/j.1365-2125.1998.00770.x.
It is the goal of Therapeutic Drug Monitoring (TDM) to use drug concentrations to manage a patient's medication regimen and optimise outcome. Limited resources require that drug assays should only be performed when they do contribute to patient management. For this to be the case a therapeutic drug monitoring service has a far greater role than just therapeutic drug measuring. This article describes the roles and functions of a Best Practice TDM service. The features which can and should be strived for in each step of the TDM process-the decision to request a drug level, the biological sample, the request, laboratory measurement, communication of results by the laboratory, clinical interpretation and therapeutic management-are discussed.
治疗药物监测（TDM）的目标是利用药物浓度来管理患者的用药方案并优化治疗效果。资源有限，这就要求仅在药物检测有助于患者管理时才进行检测。要实现这一点，治疗药物监测服务的作用远不止于药物检测。本文描述了最佳实践TDM服务的作用和功能。文中讨论了TDM过程每个步骤中能够且应该追求的特征，即申请药物浓度检测的决定、生物样本、申请、实验室检测、实验室结果传达、临床解读以及治疗管理。
