Pavlopoulos P M, Konstantinidou A E, Agapitos E, Christodoulou C N, Davaris P
Department of Pathology, National University of Athens, 115 27, Goudi, Athens, Greece.
Pediatr Dev Pathol. 1998 Nov-Dec;1(6):487-93. doi: 10.1007/s100249900067.
The possible association of a single umbilical artery (SUA) with malformations of vascular etiology is investigated in this study. Four hundred twelve fetal and embryonic autopsies showing one or more congenital malformations, collected over 7 years, were reviewed. Microscopic confirmation of a SUA was evident in 20 cases (4.85%). The two subgroups with 2 (nA = 20) or 3 umbilical vessels (nB = 392) were compared with each other, in relation to the frequency of malformations per organ system. In the group of fetuses with congenital malformations, no association was observed between SUA and the incidence of CNS, cardiac, pulmonary, or genital malformations. However, there was a significantly higher incidence of atresia of hollow organs (P = 0.003), renal aplasia (P = 0.034), and limb reduction defects (LRD) (P = 0.0383) when only a single umbilical artery was present. This suggests a possible etiopathogenetic association of SUA with congenital malformations of vascular etiology. Furthermore, the findings of our study suggest that prenatal identification of a SUA warrants a thorough search for atresias, renal aplasia, and LRD-type malformations.
本研究调查了单脐动脉（SUA）与血管病因性畸形之间可能存在的关联。回顾了7年间收集的412例显示一种或多种先天性畸形的胎儿和胚胎尸检病例。20例（4.85%）经显微镜证实存在单脐动脉。将具有2条（nA = 20）或3条脐血管（nB = 392）的两个亚组，就每个器官系统的畸形频率进行了相互比较。在先天性畸形胎儿组中，未观察到单脐动脉与中枢神经系统、心脏、肺部或生殖器畸形的发生率之间存在关联。然而，当仅存在一条单脐动脉时，中空器官闭锁（P = 0.003）、肾发育不全（P = 0.034）和肢体短小缺陷（LRD）（P = 0.0383）的发生率显著更高。这表明单脐动脉与血管病因性先天性畸形之间可能存在病因学关联。此外，我们的研究结果表明，产前识别单脐动脉需要彻底排查闭锁、肾发育不全和肢体短小缺陷型畸形。
