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一个基因座控制区调控酵母重组。

A locus control region regulates yeast recombination.

作者信息

Haber J E

机构信息

Rosenstiel Center, Keck Institute for Cellular Visualization, Brandeis University, Waltham, MA 02254, USA.

出版信息

Trends Genet. 1998 Aug;14(8):317-21. doi: 10.1016/s0168-9525(98)01501-7.

DOI:10.1016/s0168-9525(98)01501-7
PMID:9724964
Abstract

The yeast Saccharomyces can switch its mating type by a highly choreographed recombination event in which 'a' or 'alpha' sequences at the mating-type (MAT) locus are replaced by opposite mating-type sequences copied from one of two donors, HML and HMR, located near the two ends of the same chromosome III. MAT alpha cells 'know' to choose HML, while MAT alpha cells preferentially recombine with HMR. Donor preference is regulated by a 250 bp recombination enhancer, that controls recombination of the entire left arm of chromosome III. Recent studies have shown how this locus-control region is turned on and off.

摘要

酵母酿酒酵母可以通过高度编排的重组事件来切换其交配型，在该事件中，位于交配型（MAT）位点的“a”或“α”序列被从位于同一条III号染色体两端附近的两个供体HML和HMR之一复制的相反交配型序列所取代。MATα细胞“知道”选择HML，而MATa细胞则优先与HMR重组。供体偏好由一个250 bp的重组增强子调控，该增强子控制III号染色体整个左臂的重组。最近的研究表明了这个基因座控制区域是如何开启和关闭的。

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引用本文的文献

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