Steck A J, Schaeren-Wiemers N, Hartung H P
Department of Neurology, University of Basel, Switzerland.
Curr Opin Neurol. 1998 Aug;11(4):311-8. doi: 10.1097/00019052-199808000-00006.
The highly complex and multiple mechanisms responsible for the development of demyelinating neuropathies are reviewed, in particular Guillain-Barré syndrome and its variant Miller Fisher syndrome, chronic inflammatory demyelinating neuropathy, multifocal motor neuropathy, anti-myelin-associated glycoprotein neuropathy, as well as experimental models. Recent investigations into the role of auto antibodies against myelin proteins, or glycolipids have given insights into the pathogenesis of demyelinating inflammatory neuropathies.
本文综述了导致脱髓鞘性神经病发生的高度复杂且多样的机制,尤其关注吉兰 - 巴雷综合征及其变异型米勒 - 费希尔综合征、慢性炎症性脱髓鞘性多发性神经病、多灶性运动神经病、抗髓鞘相关糖蛋白神经病,以及相关实验模型。近期针对抗髓鞘蛋白或糖脂自身抗体作用的研究,为脱髓鞘性炎性神经病的发病机制提供了新见解。