一名患有性早熟和克兰费尔特综合征的儿童的纵隔生殖细胞肿瘤。

Mediastinal germ cell tumor in a child with precocious puberty and Klinefelter syndrome.

作者信息

Bebb G G, Grannis F W, Paz I B, Slovak M L, Chilcote R

机构信息

Department of General and Oncologic Surgery, City of Hope National Medical Center, Duarte, California 91010, USA.

出版信息

Ann Thorac Surg. 1998 Aug;66(2):547-8. doi: 10.1016/s0003-4975(98)00504-9.

DOI:10.1016/s0003-4975(98)00504-9

PMID:9725401

Abstract

An 8-year-old boy presented with precocious puberty and a mediastinal mass. A computer search showed that this rare presentation is most common with germ cell tumor of the mediastinum in children with Klinefelter syndrome. The tumor was completely resected after preoperative chemotherapy, and the patient is well 2 years after the operation. In patients with Klinefelter syndrome, germ cell tumors are 50 times more common than in patients without Klinefelter syndrome, usually contain nonseminomatous elements, present at an earlier age, and are seldom testicular in location.

摘要

一名8岁男孩出现性早熟和纵隔肿块。计算机检索显示，这种罕见表现最常见于患有克兰费尔特综合征的儿童纵隔生殖细胞肿瘤。肿瘤在术前化疗后被完全切除，术后2年患者情况良好。在克兰费尔特综合征患者中，生殖细胞肿瘤的发生率比无克兰费尔特综合征的患者高50倍，通常含有非精原细胞瘤成分，发病年龄较早，且很少位于睾丸。