格列喹酮-PVP K30固体分散体的制备及溶出速率
Preparation and dissolution rate of gliquidone-PVP K30 solid dispersions.
作者信息
Martnez P, Goñi M M, Cantera R G, Martin C, Dios-Viéitez C, Martínez-Ohárriz C
机构信息
Department of Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, University of Navarra, Pamplona, Spain.
出版信息
Eur J Drug Metab Pharmacokinet. 1998 Apr-Jun;23(2):113-7. doi: 10.1007/BF03189325.
PMID:9725467
Abstract
Solid dispersions of gliquidone in PVP K30 were prepared by the solvent method. These dispersions were characterized using X-ray diffraction. In comparison with the drug alone, the physical mixtures and even more the solid dispersions showed an increase in the dissolution rate. Moreover these solid dispersions were stable during storage.
摘要
采用溶剂法制备了格列喹酮在聚乙烯吡咯烷酮K30中的固体分散体。通过X射线衍射对这些分散体进行了表征。与单纯药物相比，物理混合物尤其是固体分散体的溶出速率有所提高。此外，这些固体分散体在储存过程中是稳定的。
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