Samra J S, Giles S L, Summers L K, Evans R D, Arner P, Humphreys S M, Clark M L, Frayn K N
Oxford Lipid Metabolism Group, Nuffield Department of Clinical Medicine, Radcliffe Infirmary, Oxford, UK.
Int J Obes Relat Metab Disord. 1998 Aug;22(8):806-12. doi: 10.1038/sj.ijo.0800664.
To test the hypothesis that intravenous infusion of lipid would bring about changes in adipose tissue metabolism, which would tend to spare net fat mobilization, and to attempt to identify the mediators of such responses.
The triacylglycerol (TG) emulsion, Intralipid, was infused and metabolic changes in subcutaneous adipose tissue and forearm muscle were assessed by measurements of arterio-venous differences.
Six normal male subjects aged 21-37 y, with body mass index (BMI) 23.0-25.9 kg/m2.
Plasma TG and non-esterified fatty acid (NEFA) concentrations rose during infusion as expected. The rise in systemic plasma NEFA concentration occurred despite decreased NEFA release from adipose tissue. Intralipid infusion resulted in a suppression of intracellular lipolysis in adipose tissue, by mechanisms which are not clear. Plasma leptin concentrations, measured in a search for the regulator of lipolysis, showed consistent leptin release from adipose tissue which did not change significantly with time.
The suppression of intracellular lipolysis in adipose tissue during Intralipid infusion is a new observation and may reflect a novel mechanism for regulation of fat storage.
验证静脉输注脂质会引起脂肪组织代谢变化这一假说，该变化倾向于减少净脂肪动员，并尝试确定此类反应的介质。
输注三酰甘油（TG）乳剂英脱利匹特，并通过测量动静脉差异评估皮下脂肪组织和前臂肌肉的代谢变化。
6名年龄在21 - 37岁的正常男性受试者，体重指数（BMI）为23.0 - 25.9kg/m²。
输注期间血浆TG和非酯化脂肪酸（NEFA）浓度如预期升高。尽管脂肪组织中NEFA释放减少，但全身血浆NEFA浓度仍升高。英脱利匹特输注通过尚不清楚的机制抑制了脂肪组织中的细胞内脂解。为寻找脂解调节剂而测量的血浆瘦素浓度显示，脂肪组织持续释放瘦素，且随时间无显著变化。
英脱利匹特输注期间脂肪组织中细胞内脂解受到抑制是一项新发现，可能反映了一种调节脂肪储存的新机制。
