Wills R, Henry R L, Francis J L
John Hunter Children's Hospital, New Lambton Heights, New South Wales, Australia.
J Paediatr Child Health. 1998 Aug;34(4):325-9. doi: 10.1046/j.1440-1754.1998.00197.x.
To document the frequency and severity of reactions to antibiotics in children and adolescents with cystic fibrosis (CF), to determine which drugs and routes of administration are most likely to produce reactions and to assess how these reactions limit the choice of antibiotics.
Medical records were reviewed to ascertain the number and routes of courses of antibiotics and all suspected drug reactions. Patients and their parents were interviewed about drug reactions.
Fifty-three records were suitable for analysis. Eighteen of 53 subjects had experienced a reaction (34%). The intravenous route was most allergenic, with 33% of treated patients experiencing a reaction and 9.5% of courses provoking a reaction. Piperacillin was the most allergenic antibiotic.
Drug hypersensitivity reactions are common in CF. Piperacillin is particularly allergenic. Whilst rarely life-threatening, the reactions are unpleasant and can limit our choices for antibiotic treatment of their bronchopneumonia.
记录囊性纤维化（CF）儿童和青少年对抗生素的反应频率和严重程度，确定哪些药物和给药途径最有可能产生反应，并评估这些反应如何限制抗生素的选择。
回顾病历以确定抗生素疗程的数量和途径以及所有疑似药物反应。就药物反应对患者及其父母进行了访谈。
53份记录适合分析。53名受试者中有18名经历过反应（34%）。静脉途径致敏性最高，33%的接受治疗患者出现反应，9.5%的疗程引发反应。哌拉西林是致敏性最高的抗生素。
药物过敏反应在CF中很常见。哌拉西林尤其具有致敏性。虽然很少危及生命，但这些反应令人不适，并且会限制我们对其支气管肺炎进行抗生素治疗的选择。
