Loy C S, Horne R S, Read P A, Cranage S M, Chau B, Adamson T M
Department of Paediatrics, Monash University, Monash Medical Centre, Clayton, Victoria, Australia.
J Paediatr Child Health. 1998 Aug;34(4):349-54. doi: 10.1046/j.1440-1754.1998.00244.x.
To investigate arousal from sleep in infants before and after triple antigen immunization (DTP).
Arousal thresholds were determined in both active sleep (AS) and quiet sleep (QS) the day before and the day following the first DTP immunisation in 14 infants. Arousal was induced using a pulsatile puff of air delivered alternately to the nostrils of the infant.
Arousal threshold was significantly higher in QS compared to AS in both studies (P < 0.001). Mean arousal threshold in the pre immunization study was not different from that in the post immunization study in either sleep state. Core temperature and heart rate measured at the time of stimulus delivery were both significantly elevated in the post immunisation study (P < 0.001). Sleep duration and number of awakenings from sleep were unaffected by immunization.
The first triple antigen immunisation has no effect on arousal from sleep in either AS or QS in this group of infants.
研究三联抗原免疫（白百破疫苗，DTP）前后婴儿睡眠中的觉醒情况。
对14名婴儿在首次接种白百破疫苗前一天和接种后一天，测定其主动睡眠（AS）和安静睡眠（QS）状态下的觉醒阈值。通过向婴儿鼻孔交替吹气来诱发觉醒。
在两项研究中，安静睡眠状态下的觉醒阈值均显著高于主动睡眠状态（P < 0.001）。在两种睡眠状态下，免疫前研究的平均觉醒阈值与免疫后研究的平均觉醒阈值无差异。在免疫后研究中，刺激施加时测量的核心体温和心率均显著升高（P < 0.001）。睡眠时间和睡眠中觉醒次数不受免疫影响。
在这组婴儿中，首次三联抗原免疫对主动睡眠或安静睡眠中的觉醒均无影响。
