MacLeod C
Department of Radiation Oncology, Royal Prince Alfred Hospital, Camperdown, New South Wales, Australia.
Australas Radiol. 1998 Aug;42(3):229-31. doi: 10.1111/j.1440-1673.1998.tb00500.x.
In the 1940s, 1950s and 1960s, low doses of radiotherapy were used to treat benign uterine bleeding. The cases of two women who received this form of therapy and later developed gynaecological malignancies and had high-dose pelvic radiotherapy are presented. A 76-year-old woman with an International Federation of Gynecology and Obstetrics (FIGO) stage-IIB squamous cell carcinoma of the cervix received external beam radiotherapy and intra-uterine brachytherapy and a 77-year-old women with a FIGO stage-IB endometrial adenocarcinoma received adjuvant postoperative pelvic radiotherapy. Both women had a significant past history of low-dose-rate intra-uterine irradiation for dysfunctional uterine bleeding. Therefore the theoretical question of carcinogenesis was raised, and also the practical questions of what dose had previously been given and what further dose could be safely given with regard to normal tissue tolerance.
在20世纪40年代、50年代和60年代，低剂量放疗被用于治疗良性子宫出血。本文介绍了两名接受过这种治疗形式、后来发生妇科恶性肿瘤并接受高剂量盆腔放疗的女性病例。一名76岁患有国际妇产科联盟（FIGO）IIB期宫颈鳞状细胞癌的女性接受了体外照射放疗和宫内近距离放疗，一名77岁患有FIGO IB期子宫内膜腺癌的女性接受了术后辅助盆腔放疗。两名女性都有因功能失调性子宫出血而接受低剂量率宫内照射的重要既往史。因此，引发了致癌作用的理论问题，以及之前给予了何种剂量以及就正常组织耐受性而言可以安全给予何种进一步剂量的实际问题。
