从多棘海盘车中分离和鉴定葡萄糖神经酰胺的结构

Isolation and structure of glucosylceramides from the starfish Cosmasterias lurida.

作者信息

Maier M S, Kuriss A, Seldes A M

机构信息

Departamento de Química Orgánica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, Argentina.

出版信息

Lipids. 1998 Aug;33(8):825-7. doi: 10.1007/s11745-998-0277-8.

DOI:10.1007/s11745-998-0277-8

PMID:9727615

Abstract

From the water-insoluble lipid fraction of the methylene chloride/methanol extract of the starfish Cosmasterias lurida, two new glucosylceramides together with a known glucosylceramide, ophidiacerebroside E, were isolated by chromatographic procedures and characterized by spectroscopic (1H and 13C nuclear magnetic resonance, mass spectrometry) methods. The new compounds were identified as (2S,3R,4E,8E,10E)-1-(beta-D-glucopyranosyloxy)-3 -hydroxy-2-[(R)-2-hydroxyheptadecanoyl)amino]-9-methyl-4,8,10-o ctadecatriene (3) and (2S,3R,4E,8E,10E)-1-(beta-D-glucopyranosyloxy)-3 -hydroxy-2-[(R)-2-hydroxyoctadecanoyl)amino]-9-methyl-4,8,10-oc tadecatriene (4).

摘要

从多棘槭海星（Cosmasterias lurida）的二氯甲烷/甲醇提取物的水不溶性脂质部分中，通过色谱方法分离出两种新的葡糖神经酰胺以及一种已知的葡糖神经酰胺——蛇形脑苷脂E，并通过光谱法（1H和13C核磁共振、质谱）对其进行了表征。新化合物被鉴定为(2S,3R,4E,8E,10E)-1-(β-D-吡喃葡萄糖氧基)-3-羟基-2-[(R)-2-羟基十七烷酰基]氨基-9-甲基-4,8,10-十八碳三烯（3）和(2S,3R,4E,8E,10E)-1-(β-D-吡喃葡萄糖氧基)-3-羟基-2-[(R)-2-羟基十八烷酰基]氨基-9-甲基-4,8,10-十八碳三烯（4）。