反向突变——遗传性疾病的自发改善或治愈？

Reverse mutations--spontaneous amelioration or cure of inherited disorders?

作者信息

Wahn V, Stephan V, Hirschhorn R

机构信息

Universität-Kinderklinik, Düsseldorf, Germany.

出版信息

Eur J Pediatr. 1998 Aug;157(8):613-7. doi: 10.1007/s004310050896.

DOI:10.1007/s004310050896

PMID:9727841

Abstract

Some recent publications indicate that inherited disorders can ameliorate or possibly disappear if mutations responsible for the disease revert to normal. This review tries to summarize our current knowledge about reverse mutations as this information may be of special interest for attempts at somatic gene therapy.

摘要

最近的一些出版物表明，如果导致疾病的突变恢复正常，遗传性疾病可以得到改善或可能消失。本综述试图总结我们目前关于反向突变的知识，因为这些信息可能对体细胞基因治疗的尝试具有特殊意义。