Warde P, Jewett M A
Department of Radiation Oncology, University of Toronto, Ontario, Canada.
Urol Clin North Am. 1998 Aug;25(3):425-33. doi: 10.1016/s0094-0143(05)70032-x.
Postorchidectomy treatment options in patients with stage I seminoma include surveillance (reserving treatment for patients who relapse), adjuvant radiation therapy (RT), and adjuvant chemotherapy. Adjuvant retroperitoneal RT remains the treatment of choice in most centers; however, the success of surveillance in stage I nonseminomatous germ cell testis tumors, the establishment of curative chemotherapy for advanced disease, and the improvements in CT have led to re-examination of the standard treatment approach. The available data from the surveillance and adjuvant RT series suggest that almost 100% of patients with stage I testicular seminoma are cured, whichever approach is chosen. This article presents an overview of the available information on all treatment options, the pros and cons of each approach, and indications for where surveillance fits into the armamentarium of clinicians dealing with this disease.
I期精原细胞瘤患者睾丸切除术后的治疗选择包括观察等待(为复发患者保留治疗手段)、辅助性放射治疗(RT)和辅助性化疗。辅助性腹膜后RT在大多数中心仍是首选治疗方法;然而,I期非精原细胞性生殖细胞睾丸肿瘤观察等待的成功、晚期疾病根治性化疗的确立以及CT技术的改进,促使人们重新审视标准治疗方法。观察等待和辅助性RT系列的现有数据表明,无论选择哪种方法,几乎100%的I期睾丸精原细胞瘤患者都能治愈。本文概述了所有治疗选择的现有信息、每种方法的利弊,以及观察等待在治疗这种疾病的临床医生的治疗手段中的适用情况。