Moreira J F, Neves M C, Lopes G, Gomes A R
Department of Orthopaedics, Hospital Curry Cabral, Lisbon, Portugal.
Int Orthop. 1998;22(3):193-6. doi: 10.1007/s002640050240.
We describe slipped capital femoral epiphysis in 4 members of a black, obese family, who were all first-degree relatives. The aetiology of slipped capital femoral epiphysis is unknown, although it is thought to be multifactorial. Genetic predisposition and environmental factors have been associated with the condition. A familial incidence with at least two cases in the same family has been reported. In epidemiological studies, this incidence ranges from 3% to 35%. Our cases were investigated in an attempt to find a possible aetiological genetic factor. A genetic predisposition with an autosomal dominant pattern of transmission is suggested, although environmental variables must be considered as provocative factors.
我们描述了一个肥胖的黑人家庭中的4名成员患有股骨头骨骺滑脱，他们均为一级亲属。尽管股骨头骨骺滑脱的病因尚不清楚，但被认为是多因素的。遗传易感性和环境因素与该病有关。已有报道称同一家庭中至少有两例发病的家族性发病率。在流行病学研究中，这种发病率在3%至35%之间。我们对这些病例进行了调查，试图找到可能的病因遗传因素。尽管环境变量必须被视为诱发因素，但提示存在常染色体显性遗传模式的遗传易感性。
