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CD30是一种CD40诱导分子，可在非抗原选择的人B细胞中负向调节CD40介导的免疫球蛋白类别转换。

CD30 is a CD40-inducible molecule that negatively regulates CD40-mediated immunoglobulin class switching in non-antigen-selected human B cells.

作者信息

Cerutti A, Schaffer A, Shah S, Zan H, Liou H C, Goodwin R G, Casali P

机构信息

Department of Pathology, Cornell University Graduate School of Medical Sciences, Cornell University Medical College, New York, New York 10021, USA.

出版信息

Immunity. 1998 Aug;9(2):247-56. doi: 10.1016/s1074-7613(00)80607-x.

DOI:10.1016/s1074-7613(00)80607-x
PMID:9729045
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4621001/
Abstract

We used our monoclonal model of germinal center maturation, CL-01 B cells, to investigate the role of CD30 in human B cell differentiation. CL-01 cells are IgM+ IgD+ CD30+ and switch to IgG, IgA, and IgE when exposed to CD40L and IL-4. Switching is hampered by CD30 coengagement, possibly through interference with the CD40-mediated NF-kappaB-dependent transcriptional activation of downstream C(H) genes. The physiological relevance of this phenomenon is emphasized by similar CD30-mediated effects in naive B cells. Expression of CD30 by these cells is induced by CD40L but is inhibited by B cell receptor coengagement and/or exposure to IL-6 and IL-12. Our data suggest that CD30 critically regulates the CD40-mediated differentiation of non-antigen-selected human B cells.

摘要

我们利用生发中心成熟的单克隆模型CL-01 B细胞，来研究CD30在人类B细胞分化中的作用。CL-01细胞为IgM+ IgD+ CD30+，当暴露于CD40L和IL-4时会转换为IgG、IgA和IgE。CD30共刺激会阻碍这种转换，可能是通过干扰CD40介导的下游C(H)基因的NF-κB依赖性转录激活。幼稚B细胞中类似的CD30介导效应强调了这一现象的生理相关性。这些细胞中CD30的表达由CD40L诱导，但受B细胞受体共刺激和/或暴露于IL-6和IL-12的抑制。我们的数据表明，CD30关键地调节非抗原选择的人类B细胞的CD40介导的分化。

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本文引用的文献

1
CD40 engagement triggers switching to IgA1 and IgA2 in human B cells through induction of endogenous TGF-beta: evidence for TGF-beta but not IL-10-dependent direct S mu-->S alpha and sequential S mu-->S gamma, S gamma-->S alpha DNA recombination.CD40激活通过内源性转化生长因子β（TGF-β）的诱导促使人类B细胞转换为IgA1和IgA2：支持TGF-β而非白细胞介素10依赖性直接的Smu→Sα以及连续的Smu→Sγ、Sγ→Sα DNA重组的证据。
J Immunol. 1998 Nov 15;161(10):5217-25.
2
CD40 ligand and appropriate cytokines induce switching to IgG, IgA, and IgE and coordinated germinal center and plasmacytoid phenotypic differentiation in a human monoclonal IgM+IgD+ B cell line.CD40配体和适当的细胞因子可诱导人单克隆IgM+IgD+B细胞系转换为IgG、IgA和IgE，并协调生发中心和浆细胞样表型分化。
J Immunol. 1998 Mar 1;160(5):2145-57.
3
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Genes Dev. 1997 Nov 1;11(21):2810-21. doi: 10.1101/gad.11.21.2810.
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CD154/CD40 and CD70/CD27 interactions have different and sequential functions in T cell-dependent B cell responses: enhancement of plasma cell differentiation by CD27 signaling.CD154/CD40和CD70/CD27相互作用在T细胞依赖性B细胞反应中具有不同且相继的功能：CD27信号增强浆细胞分化。
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Polymerase chain reaction selects a novel disintegrin proteinase from CD40-activated germinal center dendritic cells.聚合酶链反应从CD40激活的生发中心树突状细胞中筛选出一种新型整合素裂解蛋白酶。
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