CD30是一种CD40诱导分子，可在非抗原选择的人B细胞中负向调节CD40介导的免疫球蛋白类别转换。
CD30 is a CD40-inducible molecule that negatively regulates CD40-mediated immunoglobulin class switching in non-antigen-selected human B cells.
作者信息
Cerutti A, Schaffer A, Shah S, Zan H, Liou H C, Goodwin R G, Casali P
机构信息
Department of Pathology, Cornell University Graduate School of Medical Sciences, Cornell University Medical College, New York, New York 10021, USA.
出版信息
Immunity. 1998 Aug;9(2):247-56. doi: 10.1016/s1074-7613(00)80607-x.
Abstract
We used our monoclonal model of germinal center maturation, CL-01 B cells, to investigate the role of CD30 in human B cell differentiation. CL-01 cells are IgM+ IgD+ CD30+ and switch to IgG, IgA, and IgE when exposed to CD40L and IL-4. Switching is hampered by CD30 coengagement, possibly through interference with the CD40-mediated NF-kappaB-dependent transcriptional activation of downstream C(H) genes. The physiological relevance of this phenomenon is emphasized by similar CD30-mediated effects in naive B cells. Expression of CD30 by these cells is induced by CD40L but is inhibited by B cell receptor coengagement and/or exposure to IL-6 and IL-12. Our data suggest that CD30 critically regulates the CD40-mediated differentiation of non-antigen-selected human B cells.
摘要
我们利用生发中心成熟的单克隆模型CL-01 B细胞，来研究CD30在人类B细胞分化中的作用。CL-01细胞为IgM+ IgD+ CD30+，当暴露于CD40L和IL-4时会转换为IgG、IgA和IgE。CD30共刺激会阻碍这种转换，可能是通过干扰CD40介导的下游C(H)基因的NF-κB依赖性转录激活。幼稚B细胞中类似的CD30介导效应强调了这一现象的生理相关性。这些细胞中CD30的表达由CD40L诱导，但受B细胞受体共刺激和/或暴露于IL-6和IL-12的抑制。我们的数据表明，CD30关键地调节非抗原选择的人类B细胞的CD40介导的分化。
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