Bunzel R, Blümcke I, Cichon S, Normann S, Schramm J, Propping P, Nöthen M M
Institute of Human Genetics, University of Bonn, Wilhelmstr. 31, D-53111, Bonn, Germany.
Brain Res Mol Brain Res. 1998 Aug 15;59(1):90-2. doi: 10.1016/s0169-328x(98)00146-6.
We have examined the imprinting status of the serotonin-2A (5-HT2A) receptor gene (HTR2A) in a series of 41 tissue samples from human adult brain. Using a HpaII RFLP polymorphism in the coding region, we obtained evidence of monoallelic expression of HTR2A in 4 out of 18 informative individuals. However, biallelic expression of HTR2A was observed in other individuals (14/18), suggesting that within the human population HTR2A imprinting in brain is polymorphic.
我们检测了来自人类成人大脑的41个组织样本中5-羟色胺2A（5-HT2A）受体基因（HTR2A）的印记状态。利用编码区域中的HpaII限制性片段长度多态性，我们在18个信息充分的个体中的4个个体中获得了HTR2A单等位基因表达的证据。然而，在其他个体（14/18）中观察到HTR2A的双等位基因表达，这表明在人类群体中，大脑中HTR2A的印记是多态性的。
