投射至延髓头端腹外侧区的下丘脑室旁核中的神经元不会因低血压而被激活。

Neurons in the hypothalamic paraventricular nucleus that project to the rostral ventrolateral medulla are not activated by hypotension.

作者信息

Badoer E

机构信息

Department of Medicine, Monash University, Monash Medical Centre, Clayton Rd., Clayton 3168, Melbourne, Victoria, Australia.

出版信息

Brain Res. 1998 Aug 10;801(1-2):224-7. doi: 10.1016/s0006-8993(98)00560-5.

DOI:10.1016/s0006-8993(98)00560-5

PMID:9729400

Abstract

The retrogradely-transported tracer, rhodamine-tagged microspheres was injected into the pressor region of the rostral ventrolateral medulla (RVLM) to enable detection of paraventricular neurons in the hypothalamus that project to the RVLM. The protein, Fos, was detected immunohistochemically and used to highlight neurons that were activated by hypotension (-16+/-5 mmHg) induced by diazoxide (30 mg/kg s.c.). Compared to controls, Fos production was increased by three-fold in the parvocellular paraventricular nucleus but there was no significant increase in the number of retrogradely-labelled cells that expressed Fos. The results suggest paraventricular nucleus (PVN) neurons projecting to the RVLM are not activated by hypotension.

摘要

将逆行运输示踪剂罗丹明标记的微球注入延髓头端腹外侧区（RVLM）的升压区，以检测下丘脑向RVLM投射的室旁核神经元。通过免疫组织化学方法检测蛋白质Fos，并用于突出显示由二氮嗪（30mg/kg皮下注射）诱导的低血压（-16±5mmHg）激活的神经元。与对照组相比，小细胞室旁核中Fos的产生增加了三倍，但表达Fos的逆行标记细胞数量没有显著增加。结果表明，投射到RVLM的室旁核（PVN）神经元不会因低血压而被激活。