Shafton A D, Ryan A, Badoer E
Department of Medicine, Monash University, Monash Medical Centre, 246 Clayton Rd., Clayton 3168, Vic., Australia.
Brain Res. 1998 Aug 10;801(1-2):239-43. doi: 10.1016/s0006-8993(98)00587-3.
The hypothalamic paraventricular nucleus (PVN) projects to the rostral ventrolateral medulla (RVLM) and to the intermediolateral cell column (IML) of the spinal cord. The present study determined whether the same neurons can innervate both regions. In each rat, two retrogradely-transported tracers, microspheres tagged with fluorescein or rhodamine, were injected into the left lower thoracic/upper lumbar IML (fluorescein) and into the pressor region of the left RVLM (rhodamine). In the PVN over 90% of the neurons labelled with either tracer were found ipsilateral to the injection site. Double labelled cells averaged almost one-third of the spinally-projecting cells in four of the five animals. In the remaining animal, there were few double-labelled cells. The results suggest that a population of PVN neurons innervates both the lower-thoracic/upper lumbar IML and the RVLM.
下丘脑室旁核（PVN）投射至延髓头端腹外侧区（RVLM）和脊髓中间外侧细胞柱（IML）。本研究确定了同一神经元是否能支配这两个区域。在每只大鼠中，将两种逆行运输的示踪剂，即标记有荧光素或罗丹明的微球，分别注入左下腹胸段/上腰段IML（荧光素）和左RVLM的升压区（罗丹明）。在PVN中，超过90%用任一示踪剂标记的神经元位于注射部位同侧。在五只动物中的四只，双标记细胞平均几乎占脊髓投射细胞的三分之一。在其余一只动物中，双标记细胞很少。结果表明，一群PVN神经元支配下腹胸段/上腰段IML和RVLM。
