Lange Y, Steck T L
Department of Pathology, Rush Presbyterian St Luke's Medical Center, Chicago, IL 60612, USA.
Curr Opin Struct Biol. 1998 Aug;8(4):435-9. doi: 10.1016/s0959-440x(98)80119-x.
What is the connection among the following three medical conditions: Niemann-Pick type C disease (a cause of mental retardation and early death), systemic lipidosis (in which an obscure side effect of numerous drugs transforms lysosomes into lamellar bodies), and holoprosencephaly (a catastrophe in embryonic development)? Recent evidence suggests that the pathogenesis in each use involves impaired sensing of cellular cholesterol.
尼曼-皮克C型病（智力发育迟缓及过早死亡的一个病因）、系统性脂质沉积症（众多药物的一种不明副作用会将溶酶体转变为板层小体）和前脑无裂畸形（胚胎发育中的一种严重病变）？最近的证据表明，每种病症的发病机制都涉及细胞胆固醇感知受损。
