Simko F, Pechánová O, Bernátová I, Gvozdjáková A, Kucharská J, Hulín I, Bada V, Turcáni M
Institute of Pathophysiology, Faculty of Medicine, Comenius University, Bratislava, Slovak Republic.
Physiol Res. 1997;46(6):419-25.
We investigated the effect of captopril on the growth of the left ventricle in an experimental model of aortic insufficiency. Four groups of rabbits were studied 28 days after experimental intervention: 1. control, 2. control with captopril (10 mg/kg/day), 3. aortic insufficiency, 4. aortic insufficiency with captopril (10 mg/kg/day). Aortic insufficiency induced hypertrophic growth of the left ventricle demonstrated by increased weight and ribonucleic acid (RNA) concentration. Administration of captopril only slightly attenuated the weight increase of the left ventricle and the increase in concentration of left ventricular RNA. However, captopril reduced the concentration of left ventricular deoxyribonucleic acid (DNA) both in the control and even more in the group with aortic insufficiency. The chronic haemodynamic overload enhanced mitochondrial respiration in the left ventricle which was not influenced by captopril. We conclude that captopril in the dose 10 mg/kg/day did not prevent hypertrophy of the left ventricle but reduced left ventricular DNA concentration.
我们在主动脉瓣关闭不全的实验模型中研究了卡托普利对左心室生长的影响。在实验干预28天后，对四组兔子进行了研究：1. 对照组；2. 服用卡托普利（10毫克/千克/天）的对照组；3. 主动脉瓣关闭不全组；4. 服用卡托普利（10毫克/千克/天）的主动脉瓣关闭不全组。主动脉瓣关闭不全导致左心室肥厚性生长，表现为重量增加和核糖核酸（RNA）浓度升高。给予卡托普利仅略微减轻了左心室重量的增加和左心室RNA浓度的升高。然而，卡托普利降低了对照组以及主动脉瓣关闭不全组中左心室脱氧核糖核酸（DNA）的浓度。慢性血流动力学超负荷增强了左心室的线粒体呼吸，这不受卡托普利的影响。我们得出结论，每天10毫克/千克剂量的卡托普利不能预防左心室肥厚，但可降低左心室DNA浓度。
