Ishikawa K, Shimoda K, Shiraishi N, Adachi Y, Kitano S
Department of Surgery I, Oita Medical University, Japan.
Jpn J Clin Oncol. 1998 Jun;28(6):374-7. doi: 10.1093/jjco/28.6.374.
The effect of administering low-dose cisplatin (CDDP)-5-fluorouracil (5-FU) postoperatively on the activity of the immune system is not known. To clarify the effect on natural killer (NK) cell activity of treatment with low-dose CDDP-5-FU, we compared NK cell activity after surgery for gastrointestinal cancer in patients treated with low-dose CDDP-5-FU, a bolus dose of mitomycin C (MMC) or no anticancer drug.
Sixty-two patients consisted of three groups: low-dose CDDP-5-FU (n = 15), MMC (n = 20) and no-drug (n = 27). Chemotherapy was initiated immediately after surgery. NK cell activity was measured on the day before surgery (pre-op) and on postoperative days 7 (POD7) and 21 (POD21).
The NK cell activities of the CDDP-5-FU group were 37.7% at pre-op, 36.1% on POD7 and 33.6% on POD21. However, the NK cell activities in the no-drug and MMC groups were significantly decreased on POD7 (from 36.6 to 24.8% and from 31.4 to 16.6%, respectively). The NK cell activity in the MMC group remained depressed on POD21 (18.6%) whereas that in the no-drug group recovered (31.6%).
Consecutive administration of low-dose CDDP-5-FU appears to be useful as postoperative adjuvant chemotherapy because of its preventive effect on NK cell suppression after surgery.
术后给予低剂量顺铂（CDDP）-5-氟尿嘧啶（5-FU）对免疫系统活性的影响尚不清楚。为阐明低剂量CDDP-5-FU治疗对自然杀伤（NK）细胞活性的影响，我们比较了接受低剂量CDDP-5-FU、大剂量丝裂霉素C（MMC）或不使用抗癌药物治疗的胃肠道癌患者术后的NK细胞活性。
62例患者分为三组：低剂量CDDP-5-FU组（n = 15）、MMC组（n = 20）和无药物组（n = 27）。术后立即开始化疗。在手术前一天（术前）、术后第7天（POD7）和第21天（POD21）测量NK细胞活性。
CDDP-5-FU组的NK细胞活性在术前为37.7%，POD7时为36.1%，POD21时为33.6%。然而，无药物组和MMC组的NK细胞活性在POD7时显著降低（分别从36.6%降至24.8%和从31.4%降至16.6%）。MMC组的NK细胞活性在POD21时仍处于较低水平（18.6%），而无药物组的NK细胞活性恢复（31.6%）。
连续给予低剂量CDDP-5-FU作为术后辅助化疗似乎是有用的，因为它对术后NK细胞抑制有预防作用。
