Simón C, Caballero-Campo P, García-Velasco J A, Pellicer A
Instituto Valenciano de Infertilidad and Department of Pediatrics, Obstetrics and Gynecology, Valencia University, Spain.
J Reprod Immunol. 1998 Jul;38(2):169-93. doi: 10.1016/s0165-0378(98)00031-x.
Chemokines are a new family of cytokines specialised in attracting leukocytes, acting in physiological conditions and in pathological processes. A wide variety of cell types in response to exogenous irritants or endogenous mediators of the inflammatory reaction produce them. Pivotal parts of reproductive function are based on inflammatory like processes wherein different leukocytes subsets are recruited and activated to produce paracrine autocrine effects in which cytokines and growth factors are implicated. Since chemokines control leukocyte trafficking and belong to the cytokine superfamily, in this review we analyze the implications of these molecules and related cells in ovulation, embryonic implantation, menstruation, parturition and their role in pathological process such as preterm delivery, endometriosis, ovarian hyperstimulation syndrome and HIV infection.
趋化因子是一类新的细胞因子家族，专门负责吸引白细胞，在生理条件和病理过程中发挥作用。多种细胞类型在对外源性刺激物或炎症反应的内源性介质作出反应时会产生趋化因子。生殖功能的关键部分基于类似炎症的过程，在此过程中，不同的白细胞亚群被募集并激活，以产生涉及细胞因子和生长因子的旁分泌自分泌效应。由于趋化因子控制白细胞的迁移且属于细胞因子超家族，因此在本综述中，我们分析了这些分子及相关细胞在排卵、胚胎着床、月经、分娩中的作用，以及它们在早产、子宫内膜异位症、卵巢过度刺激综合征和HIV感染等病理过程中的作用。
