Suppola J P, Kuikka A, Vaara M, Valtonen V V
Department of Bacteriology and Immunology, Haartman Institute, University of Helsinki, Finland.
Scand J Infect Dis. 1998;30(2):153-7. doi: 10.1080/003655498750003546.
The purpose of our study was to determine retrospectively the risk factors for the acquisition of Enterococcus faecalis vs E. faecium bacteraemia, as well as the clinical outcomes of these patients. 62 patients with Enterococcus faecalis bacteraemia were compared to 31 patients with E. faecium bacteraemia. Haematologic malignancies, neutropenia, high-risk source and previous use of aminoglycosides, carbapenems, cephalosporins and clindamycin were significantly associated with E. faecium bacteraemia. Instead, urinary catheterization was found to be related to Enterococcus faecalis bacteraemia. The mortality rates within 7 d and 30 d were 13% and 27%, respectively, in patients with E. faecalis bacteraemia and 6% and 29%, respectively, in patients with E. faecium bacteraemia. There was no difference in mortality between E. faecalis and E. faecium bacteraemia, nor was there a difference in seriousness of disease at the time of bacteraemia. In the subgroups of patients with monomicrobial or clinically significant E. faecalis vs E. faecium bacteraemia, the mortality rates were similar to the results of all subjects. Our results do not support the theory that E. faecium would be a more virulent organism than E. faecalis.
我们研究的目的是回顾性地确定粪肠球菌与屎肠球菌菌血症的危险因素，以及这些患者的临床结局。将62例粪肠球菌菌血症患者与31例屎肠球菌菌血症患者进行比较。血液系统恶性肿瘤、中性粒细胞减少、高危来源以及先前使用氨基糖苷类、碳青霉烯类、头孢菌素类和克林霉素与屎肠球菌菌血症显著相关。相反，发现导尿与粪肠球菌菌血症有关。粪肠球菌菌血症患者7天和30天的死亡率分别为13%和27%，屎肠球菌菌血症患者分别为6%和29%。粪肠球菌和屎肠球菌菌血症之间的死亡率没有差异，菌血症发生时疾病的严重程度也没有差异。在单微生物或具有临床意义的粪肠球菌与屎肠球菌菌血症患者亚组中，死亡率与所有受试者的结果相似。我们的结果不支持屎肠球菌比粪肠球菌毒性更强的理论。
