Boman L, Ericson M
Department of Surgery, Lycksele Hospital, Sweden.
Obes Surg. 1997 Apr;7(2):125-7. doi: 10.1381/096089297765556006.
Serum Lipoprotein A [Lp(a)] is considered an independent risk factor for cardiovascular disease. Reduction of other risk factors such as serum triglycerides and serum cholesterol is seen after weight reduction but it has been difficult to demonstrate a similar reduction of Lp(a). In this study Lp(a) is studied following weight reduction after intestinal bypass surgery for obesity.
A cross-sectional study was performed in which Lp(a) levels were compared between patients operated with intestinal bypass surgery for obesity (bilio-intestinal bypass) and a closely matched control group. The controls were chosen so as to correspond to the operated patients' preoperative body mass indices.
The operated group had reduced their body mass index from a mean of 42 kg/m2 to a mean of 29 kg/m2 and had a significantly lower mean serum Lp(a) level (113 mg/l, SEM 34) than controls (207 mg/l, SEM 37), p < 0.05.
Lowered Lp(a) levels are correlated to substantial weight loss following intestinal bypass surgery for obesity.
血清脂蛋白A [Lp(a)] 被认为是心血管疾病的独立危险因素。体重减轻后，血清甘油三酯和血清胆固醇等其他危险因素会降低，但一直难以证明Lp(a) 会有类似程度的降低。在本研究中，对肥胖患者进行肠道搭桥手术后体重减轻时的Lp(a) 进行了研究。
进行了一项横断面研究，比较了接受肥胖肠道搭桥手术（胆肠搭桥）的患者与密切匹配的对照组之间的Lp(a) 水平。选择对照组以使其与手术患者的术前体重指数相对应。
手术组的体重指数从平均42 kg/m² 降至平均29 kg/m²，平均血清Lp(a) 水平（113 mg/l，标准误34）显著低于对照组（207 mg/l，标准误37），p < 0.05。
肥胖肠道搭桥手术后Lp(a) 水平降低与体重显著减轻相关。
